리포폴리사카라이드와 갈락토사민의 투여로 인한 생쥐 치사율에 미치는 글리시라진의 억제효과

• 영문명: Inhibitory Effect of Glycyrrhizin on the Lethality Induced by Lipopolysaccharide and Galactosamine
• 발행기관: 대한약학회
• 저자명: 오창욱(Chang Wook Oh) 송경(Kyung Song) 박은전(Eun Jeon Park) 손동환(Dong Hwan Sohn) 김재백(Jae Baek Kim) 고건일(Geon Il Ko)
• 간행물 정보: 『약학회지』제40권 제1호 (1996년), 84~89쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.02.28

영문 초록

This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injected intravenously as a multiple dose at 20, 15, 10, 5, and O hr before galactosamine and lipopolysaccharide coadministration. Lethality and tumor necrosis factor (TNFalpha) level in serum were surveyed as markers of glycyrrhizin effect. Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20, 15, 10, 5 and O hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNFalpha level.

키워드

Glycyrrhizin Lipopolysaccharide Galactosamine Tumor Necrosis Factor α.