위장관 수술환자에서 겐타마이신의 임상약물동태

• 영문명: Clinical Pharmacokinetics of Gentamicin in Gastrointestinal Surgical Patients
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi) 문홍섭(Hong Seog Moon) 최인(In Choi) 범진필(Jin Pil Burm)
• 간행물 정보: 『약학회지』제40권 제1호 (1996년), 1~9쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.02.28

영문 초록

The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korean normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were 0.226 +/- 0.032, 0.231 +/- 0.063L/Kg and 0.357 +/- 0.024, 0.337 +/- 0.041hr-1 for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters, KS and VS were 0.00344 +/- 0.00049(hr.ml/min/1.73m2)-1 and 0.214 +/- 0.0502L/Kg for gastrointestinal surgical patients using NPEM method. The V and K were 0.216 +/- 0.048L/Kg and 0.336 +/- 0.043hr-1 for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetics between NLSR and Bayesian analysis in gastrointestinal surgical patient.

키워드

Gentamicin population pharmacokinetics gastrointestinal surgical patient nonlinear least square regression analysis nonparametric expected maximum(NPEM) Bayesian analysis.