마갈드레이트의 합성조건과 그 현탁액의 유동학적 특성

• 영문명: Synthesis Conditions of Magaldrate and Rheological Characteristics of its Aqueous Suspensions
• 발행기관: 대한약학회
• 저자명: 신화우(Wha Woo Shin) 최광식(Kwang Sik Choi)
• 간행물 정보: 『약학회지』제40권 제1호 (1996년), 25~35쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.02.28

영문 초록

Magaldrate. an antiacid was synthesized by reacting magnesium oxide, aluminum sulfate, and dried aluminum hydroxide gel. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of Magaldrate were as follows: Reaction temperature; 61~85oC, concentration of two reactants. Mgo and Al(OH)3: 16~19.8%, molar concentration ratio of two reactants, [MgO]/[Al(OH)3]; 4.2~5.0, temperature of washing water; 36~41oC and drying temperature of the product: 76~80oC. Magaldrate was synthesized under the optimum synthesis conditions and identified by analyzing the chemical composition, and by differential scanning calorimetry and X-ray diffraction method. The Magaldrate sample synthesis under these conditions was used to prepare 15.6% Magaldrate original suspension which was utilized to make 13% Magaldrate suspension dispered in various concentrations of eight types of suspending agents. The acid-neutralizing capacity of 13% Magaldrate suspension dispersed in 0.25% suspending agents was examined by Rosset-Rice method. The maximum pH was reached within 1 minute in all suspension tested, and duration maintained between pH 3~5 was decreased in the order of Na alginate Na silicate(meta) Veegum HV pectin agar>Na>CMC>xanthan gum>bentonite. It was found that the hysteresis loop area was increased with temperature in the case of Riopan Plus and the addition of agar, whereas the area was decreased with temperature in the case of the addition of Na alginate and xanthan gum. 13% Magaldrate suspension tends to sediment by the addition of bentonite.

키워드

Synthesis of magaldrate Box-Wilson experimental design Rosset— Rice method rheological properties.