7-O-(alpha-L-람노피라노실) 또는 7-O-(4''-아미노-alpha-L-람노피라노실)-다우노마이시논과 -아드리아마이시논 유도체의 합성과 항암활성

• 영문명: Synthesis and Antitumor Activity of 7-O-(alpha-L-rhamnopyranosyl) or 7-O-(4''-amino-alpha-L-rhamnopyranosyl)-daunomycinone and -adriamycinone Derivatives
• 발행기관: 대한약학회
• 저자명: 옥광대(Kwang Dae Ok) 박정배(Jeong Bae Park) 김문성(Moon Sung Kim) 정동윤(Dong Yoon Jung) 안상용(Sang Yong An) 배중석(Chung Seok Bae) 양중익(Junn Ick Yang)
• 간행물 정보: 『약학회지』제40권 제1호 (1996년), 10~18쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.02.28

영문 초록

Daunirubicin and doxorubicin analogues (5,7,8,9,) in which the natural amino sugar, daunosamine, is replaced by rhamnopyranosyl or 4''-amino rhamnopyranosyl residues have been prepared. The in vitro cytotoxicity of compound 5 or 7 was similar to that of doxorubicin for P388 murine leukemic cell line. But compound 8 or 9 was less cytotoxic than doxorubicin. When administered intravenously on day 1, compound 9 showed antitumor activity comparable to that of doxorubicin against ip-inoculated L1210 murine leukemia and found to be less toxic than doxorubicin. But the in vivo antitumor activity of compound 7 or 8 was inferior to that of doxorubicin.

키워드

Anthracycline MTT assay Antitumor activity.