D-1,3-디옥솔란 및 L-1,3-옥사티올란 5-페닐세레닐 피리미딘 뉴크레오사이드의 합성

• 영문명: Synthesis of D-1,3-Dioxolane and L-1,3-Oxathiolane 5-Phenylselenyl Pyrimidine Nucleosides as Potential Antiviral Agents
• 발행기관: 대한약학회
• 저자명: 유정만(Jung Man Yoo) 문현주(Hyun Joo Moon) 정병호(Byung Ho Chung) 최보길(Bo Gil Choi) 홍준희(Joong Hee Hong) 천문우(Moon Woo Chun)
• 간행물 정보: 『약학회지』제40권 제1호 (1996년), 46~51쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.02.28

영문 초록

Eight new D-1.3-dioxolanyl and L-1,3-oxathiolanyl nucleosides containing 5-phenyl- selenyl pyrimidine bases which are expected to have antiviral activity were synthesized. Condensation of D-1,3-dioxolane acetate and L-1,3-oxathiolane acetate with 5-phenylselenyl pyrimidines gave anomeric mixtures of their nucleosides which were separated by silicagel column chromatography.

키워드

Antiviral agent D-1,3-dioxolanyl acetate L-1.3-oxathiolane acetate 5-phenylselenyluracil nucleosides 5-phenylseleny1-6-azauracil nucleosides.