천연 페놀성 화합물들의 방향족 아미노산 탈탄산효소 저해 작용

• 영문명: Inhibition of Aromatic L-Amino Acid Decarboxylase (AADC) by Some Phenolic Compounds from Medicinal Plants
• 발행기관: 대한약학회
• 저자명: 유시용(Shi Yong Ryu) 한용남(Yong Nam Han) 한병훈(Byung Hoon Han)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 791~794쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

Sixteen kinds of naturally occurring phenolic compounds including 5 stilbenes, 7 flavonoids and 4 anthraquinones were examined in the inhibitory activity against rat liver AADC(aromatic L-amino acid decarboxylase) in vitro, using 5-hydroxytryptophan as a substrate. Three hydroxystilbenes, resveratrol 1, rhapontigenin 3 and piceatanol 5, which were known to be monoamine oxidase A inhibitors, exhibited a significant inhibition against AADC(IC50 = 20, 8 and 5 pM, respectively). By the comparison of the activity of each phenolic compound, it was suggested that the 3'',4''-dihydroxyphenyl group of stilbenes or flavones was the best pharmacophore for the AADC inhibitory activity.