Elfvingia applanata 엑스가 수종 항생물질의 항균력에 미치는 병용효과

• 영문명: Antimicrobial Activity of Elfvingia applanata extract alone and in Combination with Some Antibiotics
• 발행기관: 대한약학회
• 저자명: 김영소(Young So Kim) 임교환(Kyo Hwan Rym) 이종길(Chog Kil Lee) 한성순(Seong Sun Han)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 742~748쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

As part of our search for less toxic antimicrobial agents from natural resources, the carpophores of Elfvingia applanata(Pers) KARST. was extracted with hot water. EA, the aqueous extract from the carpophores of E. applanata, was lyophilized and a dark brownish powder was obtained. Antimicrobial activity of EA was tested in vitro against Gram positive and Gram negative bacteria by serial broth dilution method, and the antimicrobial activity was expressed by minimal inhibitory concentration(MIC). Among fourteen species of bacteria tested, the antimicrobial activity of EA was the most potent against Proteus vulgaris showing MIC of 1.250mg/ml. To investigate the effect of antimicrobial combinations of EA with four kinds of antibiotics(ampicillin, cefazolin, oxytetracycline and chloramphenicol), the fractional inhibitory concentration index(FICI) was determined by checkerboard assay for each strain. The antimicrobial combinations of EA with four kinds of antibiotics resulted in synergism in four instances, but no antagonism was observed. Four instances of synergism were observed when EA was combined with ampicillin against Micrococcus luteus, with cefazolin against Bacillus subtilis, with cefazolin against Micrococcus luteus and with oxytetracycline against Staphylococcus aureus.