T 세포 하이브리도마에 의한 alpha2-Macroglogulin의 생산

• 영문명: Production of alpha2-Macroglogulin by a T Cell Hybridoma
• 발행기관: 대한약학회
• 저자명: 이종길(Chong Kil Lee) 한성순(Seong Sun Han)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 715~720쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

Alpha2-macroglobulin (alpha2-M) has been shown to have a variety of activities. One of those activities is the suppression of immune response. Characterization of the immunosuppressive factor secreted by a T cell hybridoma showed that alpha2-M was produced and secreted from the T cell hybridoma. alpha2-M was produced abundantly from the T cell hybridoma when cultured as ascites. The isolation and identification of the alpha2-M were studied using affinity chromatography and N-terminal amino acid sequencing. The extended observations were that the alpha2-M produced by the T cell hybridoma suppresses mixed lymphocyte reaction.