지유(Sanguisorbae Radix)의 항 불안 활성

• 영문명: Anxiolytic Activities of Sanguisorbae Radix
• 발행기관: 대한약학회
• 저자명: 이소영(So Young Lee) 정성현(Sung Hyun Chung)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 733~741쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

To detect anxiolytic activity from Sanguisorbae Radix we used various animal models of fear or anxiety that are sensitive to known anxiolytic drugs. While diazepam showed significant anxiolytic activities in all five animal models empolyed in this study, 5-HT3antagonist ondansetron and ethylacetate fraction of Sanguisorbae Radix did show anti-anxiety effects in social interaction and two compartment exploration tests. Ethylacetate fraction of Sanguisorbae Radix and 5-HT3 related drugs like ondansetron and buspirone, however, seem to have merit over diazepam in terms of not causing drowsiness. Among ten subtractions obtained from ethylacetate fraction of Sanguisorbae Radix by silica gel chromatography, subtraction I showed higher anxiolytic activities than subtraction DEF in two animal models, social interaction and two compartment exploration tests. There is growing evidence for the role of 5-HT in the control of anxiety. We hope that new compound(s) will be found from the active fractions of Sanguisorbae Radix as a potential anxiolytic agent in the future.