잔나비걸상 엑스의 생쥐 급성독성에 미치는 영향

• 영문명: Effect of Elfvingia applanta extract on the Acute Toxicity in Mice
• 발행기관: 대한약학회
• 저자명: 김영소(Young So Kim) 강종구(Jong koo Kang) 이종길(Chong Kil Lee) 한성순(Seong Sun Han)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 756~762쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

To investigate the acute toxicity of Elfvingia applanata(Pers) KARST, it was extracted with hot water. EA, the aqueous extract from the carpophores of E. applanata, was lyophilized and a dark brownish powder was obtained. The acute toxicity of EA was investigated in ICR mice of both sexes. Five groups of mice were administered orally and intraperitoneally with 375, 750, 1,500, 3,000, 6,000mg/kg (p.o.) and 312.5, 625, 1,250, 2,500, 5,000mg/kg (i.p.) of EA. Abnormal clinical signs related to EA were not observed and no deaths occurred. LD50 values administered orally and intraperitoneally were evaluated to be over 6,000mg/kg and over 5,000mg/kg, respectively. Gross finding of necropsy revealed no evidence of specific toxicity related to EA. There were no significant changes in body weights, serum biochemical values and histopathological changes compared with control group.