혼성 Bivalent Ligand 퀴놀론 유도체의 합성

• 영문명: Synthesis of Hybrid Bivalent Ligand Quinolone Derivatives
• 발행기관: 대한약학회
• 저자명: 이상필(Sang Pil Lee) 임채욱(Chae Uk Im) 김동순(Dong Soon Kim) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 664~672쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

Eighteen new hybrid bivalent ligand quinolones that contain two different type of pharmacophores in a single molecule were prepared and evaluated for in vitro antibacterial activity. Hybrid bivalent ligands p-nitrobenzyloxycarbonyl quinolones were prepared by the treatment of active esters of succinyl fluoroquinolones with 1,7-disubstituted fluoroquinolone carboxylic acids in DMF. Eighteen final quinolone carboxylic acids were obtained by the reduction of compounds 25~42 with hydrogen in the presence of 1001o Pd-C. Among these derivatives, compound[56] showed the most potent antibacterial activity against a wide range of microoranisms.