모노스테아린산 알루미늄이 첨가된 리피오돌-항암제 현탁액의 유동학적 특성

• 영문명: Rheological Characteristics of Lipiodol-Anticancer Suspensions Containing Aluminum Monosterarate
• 발행기관: 대한약학회
• 저자명: 오선영(Sun Young Oh) 구영순(Young Soo Ku)
• 간행물 정보: 『약학회지』제38권 제6호 (1994년), 654~663쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.12.30

영문 초록

Lipiodol-anticancer suspensions containing fluorouracil, tegafur, mitomycin C, methotrexate, or adriamycin were prepared by Shinohara method using aluminum monostearate as a dispersing stabilizer. Lipiodol-suspension showed thixotropic property when the concentration of aluminum monostearate was above 2%. Observed thixotropic area which reflects the extent of thixotropic breakdown indicated that the thixotropic property of Lipiodol-suspensions maintained for six weeks in a refrigerator(4oC). Lipiodol-anticancer suspensions containing 2% aluminum monostearate maintained a more stable suspension system compared with simple mixtures and Lipiodol-anticancer suspensions without aluminum monostearate. As the concentration of aluminum monostearate increased, the drug release from Lipiodol-anticancer suspensions was more retarded.