전형 항정신병약물과 Mianserin 병합요법에 효과적인 치료반응을 보인 음성정신분열증 1례

• 영문명: A Case of Negative Schizophrenia Responding to Combined Therapy of Typical Antipsychotics and Mianserin
• 발행기관: 대한신경정신의학회
• 저자명: 박원명 박재홍 이정태 전양환 김광수
• 간행물 정보: 『신경정신의학』제34권 제6호, 1956~1960쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.11.30

영문 초록

We experienced a case of negative schizophrenia responding to combined therapy of typical antipsychotics and mianserin. Typical antipsychotics are believed to exert their antipsychotic effects by blocking dopamine receptors or by depleting dopamine. Mianserin is a tetracyclic antidepressant, and its pharmacological profile is characterized by the potent antagonism of postsynaptic 5-HT2 receptors. Despite an increase of reports on the treatment of negative symptoms by medication, there are at present no convincing data which medication is effective in the treatment of negative schizophrenia. We suggested that mianserin should be useful in the treatment of the negative symptoms of schizophrenia and its mechanism should be dynamic interaction between serotonin system and dopamine system.

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참고문헌

키워드

Negative schizophrenia Mianserin Serotonin