정신분열증 환자의 T-cell 아형，혈청 면역글로부린: Cortisol, Prolactin, Growth Hormone의 함량

• 영문명: T-cell Subpopulations and Contents of Serum Immunoglobulins, Cortisol, Prolactin and Growth Hormone in Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 이환철 윤혜원 박철수
• 간행물 정보: 『신경정신의학』제34권 제6호, 1652~1667쪽, 전체 16쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.11.30

영문 초록

The author examined T-cell subpopulations, contents of serum immunoglobulins, and hormonal changes in 20 male schizophrenics and 24 male normal healthy persons in order to elucidate the etiology of the schizophrenia in immunological aspect. O ur results were as follows ； 1) Compared with the normal healthy persons, the schizophrenic group had significantly higher IgM level and C D 8+ cell %，and significantly lower 丁 cell %，C D 4+ cell number, C D 4+ cell %, and C D 4+ cell %, and C D 4+/C D 8 + ratio. 2) Compared with the normal healthy persons, the positive schizophrenic group had significantly lower T cell No., T cell %，CD4+ cell No., CD4+ cell % and CD4+/C D 8+ ratio. 3) Compared with the normal healthy persons, the negative schizophrenic group significantly higher C D 8+ cell % and had significantly lower T cell %, C D 4+ cell %, C D 4+/C D 8 + ratio and prolactin level. 4) Compared with the negative schizophrenics, the positive schizophrenic group had significantly lower numbers o f lymphocyte, T cell, C D 4+ cell and C D 8+ cell and had significantly lower CD8+ cell %. 5) C D 8+ cell number and C D 8+ cell % correlated significantly with the positive symptom score in the schizophrenic group. Therefore, immunological function might play some role in the etiology of schizophrenia and it is necessary to extend further research in this area.

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키워드

Schizophrenia Immunoglobulin T-cell subpopulation Cortisol Prolactin Growth hormone