한국인 정신분열증 환자의 도파민 D2 수용체 유전자의 TaqI 다형성 분포에 관한 연구

• 영문명: Distribution of the TaqI Polymorphism of the Dopamine D2 Receptor in a Korean Schizophrenic Population
• 발행기관: 대한신경정신의학회
• 저자명: 이홍석 이민수 서광윤
• 간행물 정보: 『신경정신의학』제34권 제6호, 1641~1651쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.11.30

영문 초록

Objects : The finding of contrasting results regarding an association between schizophrenia, alcoholism and the TaqI polymorphism site in the dopamine D2 receptor gene prompted us to study the distribution of this polymorphism in a Korean schizophrenic patients and controls. Method ： Schizophrenic patients(n = 72) and controls(n = 66) were examined by case-control study for distribution of the TaqI polymorphism of the dopamine D2 receptor gene in a Korean population to minimize the effect of racial differencies in gene frequencies. Results ： The frequency of the A l allele in schizophrenics and controls was 0.48 and 0.29, respectively. There was a significant difference in the frequency of the A l allele between schizophrenics and controls(x2= 11.13, p < .05), but no significant difference between positive and negative schizophrenics(x2 = 0.908, p > 0.5). Conclusion : This suggests that contribution of this gene to the liability to develop schizophrenia may be possible. However, the possibility that the gene is not a genetic determinant in the etiology of schizophrenia cannot be definitely excluded because of the intrinsic limitation of the methods of analysis, the number of subjects studied, other contradictory findings by other studies and similar increase in prevalence of the Al allele in spectrum of the disorders that share common pathophysiologic genetic mechanisms. So the present results should be considered preliminary.

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키워드

Schizophrenia Case-control study Dopamine D2 receptor Polymorphism