방사면역측정법과 화학발광면역측정법간의 숙련도 비교평가

• 영문명: The Evaluation of Proficiency Test between Radioimmunoassay and Chemiluminescence Immunoassay
• 발행기관: 대한핵의학기술학회
• 저자명: 노경운(Gyeong Woon Noh) 김태훈(Tae Hoon Kim) 김지영(Ji young Kim) 김현주(Hyun Joo Kim) 이호영(Ho Young Lee) 최준영(Joon Young Choi) 이병일(Byoeng Il Lee) 최재걸(Jae Gol Choe) 이동수(Dong Soo Lee)
• 간행물 정보: 『핵의학기술』Vol.15 No.2, 116~124쪽, 전체 9쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2011.11.30

영문 초록

Purpose: To establish accurate external quality assurance (EQA) test, cross institutional and modality tests were performed using WHO certificated reference material (CRM) and same pooled patients serum. Materials and Methods: Accuracy and precision were evaluated using CRM and pooled patients' serum for AFP, CEA, PSA, CA 125, CA 19-9, T3, T4, Tg, TSH. To evaluate the accuracy and precision, recover test and coefficient variation were measured. RIA test were performed in major 5 RIA laboratory and EIA (CLIA) test were done in 5 major EIA laboratory. same sample of CRM and pooled serum were delivered to each laboratory. Results: In 2009, mean precision of total tumor marker of RIA was 14.8±4.2% and that of EIA(CLIA) was 19.2±6.9%. In 2010, mean precision of 5 tumor marker and T3, T4, Tg, TSH was 13.8±6.1% in RIA and 15.5±7.7% in EIA (CLIA). There was no significant difference between RIA and EIA. In RIA, the coefficient variations (CV) of AFP, CEA, PSA, CA 125, T3, T4, TSH were within 20%. The CV of CA 19-9 was over 20% but there was no significant difference with EIA (CLIA) (p=0.345). In recovery test using CRM, AFP, PSA, T4, TSH showed 92~103% of recovery in RIA. In recovery test using commercial material, CEA, CA 125, CA 19-9 showed relatively lower recovery than CRM but there was no significant difference between RIA and EIA (CLIA). Conclusion: By evaluating the precision and accuracy of each test, EQA test could more accurately measured the quality of each test and performance of laboratory.

목차

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대상 및 방법

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참고문헌

키워드

External Quality Assurance Precision Recovery test CRM (certified reference material)