Exploration of Availability as a Signal Indicator about Youden Index

• 발행기관: 한국자료분석학회
• 저자명: Hee Chang Park Ji Won Kim Kwang Hyun Cho
• 간행물 정보: 『Journal of The Korean Data Analysis Society (JKDAS)』Vol.23 No.1, 11~24쪽, 전체 14쪽
• 주제분류: 자연과학 > 통계학
• 파일형태: PDF
• 발행일자: 2021.02.28

영문 초록

With the advancement of medical technology and the increasing use of drugs also came the increase in the rates of adverse drug reactions, posing a serious risk and burden to both the patients and their treating doctors, as well as a significant financial burden in the society. In drug monitoring, the voluntary reporting system of the adverse drug reactions serves a very important role in confirming the signal information about the drugs that have been sold. Signal information in this context refers to information that requires continuous observation because a causal relationship cannot be excluded even when there is insufficient data or evidence to establish any concrete causal relationship. The aim of this particular study is to assess the applicability of Youden index, which has originally been used as a tool to evaluate the accuracy of binary diagnostic tests in diagnostic medicine, as a potential signal information indicator in adverse drug reaction monitoring. This was achieved by comparing the formulae of Youden index with those of the already existing report information indicators, as well as the utilisation of the data obtained from simulation experiments.

목차

1. Introduction

2. Youden Index as a Signal Indicator

3. Consideration of Example Data

4. Conclusion

References

키워드

sensitivity signal information adverse drug reactions specificity Youden index