천연물로부터 사이클로옥시게나제-2 저해제 검색

• 영문명: Screening of Cyclooxygenase-2 (COX-2) Inhibitors from Natural Products
• 발행기관: 대한약학회
• 저자명: 문태철(Tae Chul Moon) 정규찬(Kyu Charn Chung) 손건호(Kun Ho Son) 김현표(Hyun Pyo Kim) 강삼식(Sam Sik Kang) 장현욱(Hyeun Wook Chang)
• 간행물 정보: 『약학회지』제42권 제2호 (1998년), 214~219쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.04.30

영문 초록

Tissue distributions and association of cyclooxygenase-2 (COX-2) with inflammatory have led us to search for COX-2 selective inhibitors from natural products. Conceptually, COX-2 selective inhibitors should be expected to retain anti-inflammatory efficacy by inhibition of PGs production while reducing or eliminating the gastric, renal and hemostatic side effects commonly associated with NSAIDs use. Thus, a logical approach to the treatment of inflammatory diseases should involve the inhibitors of COX-2. To develop new COX-2 inhibitors from natural products, two hundred crude drugs were screened by inhibiting PGD2 generation in bone marrow derived mast cells (BMMC). Among them, 6 methanol extracts of crude drugs such as, Bletillae rhizoma, Aconiti kgreani rhizoma, Belamcandae rhizoma, Nelumbinis semen, Gleniae radix, Aurantii immatri pericarpium inhibited more than 85% of BMMC COX-2 activity at a concentration 2.5mcg/ml.

키워드

Nonsteroidal antiinflammatory drugs(NSAIDS) Prostaglandins BMMC Cyclooxygenase-2 inhibitors Natural products.