인산 일수소칼슘의 최적합성조건

• 영문명: Optimal Synthesis Conditions of Calcium Hydrogen Phosphate
• 발행기관: 대한약학회
• 저자명: 신화우(Wha Woo Shin) 김윤설(Youn Seol Kim) 김준희(Jun Hea Kim)
• 간행물 정보: 『약학회지』제42권 제2호 (1998년), 153~158쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.04.30

영문 초록

Calcium hydrogen phosphate was synthesized by reacting calcium chloride and sodium hydrogen phosphate solution in this study. It is well known that the particle size and yield of calcium hydrogen phosphate produced is greatly affected by the synthetic conditions such as the reactant concentration, reaction temperature, reacting fine, mole ratio and drying temperature, etc. The purpose of this study is to investigate the optimum synthesis condition from the viewpoint of yield and sedimentation volume of the prepared calcium hydrogen phosphate powder according to a randomized complete block design proposed by G.E.P. Box and K.B. Wilson. It was found that the optimum synthetic conditions of calcium hydrogen phosphate were as follows: It was found that optirnum temperature range of reactant solutions was 28-38oC and 32-42oC respectively, on the viewpoint of yield and sedimentation volume. The optimum concentration range of reactant solutions was 5.5-10.0% and 6.9-7.4% respectively, on the viewpoint of yield and sedimentation volume. The optimum mole ratio of CaCl2 to Na2HPO4 was in the range of 1.2-2.0 and the optimum reacting time range was 8.5-11.0 minutes. The optimum drying temperature range was 39-41oC from the viewpoint of yield, but it was 39-43oC on the basis of sedimentation volume. Crystallographic analysis to X-ray diffraction patterns of commercially available ecalcium hydrogen phosphate and calcium hydrogen phosphate samples prepared in this study suggested that all samples tested belonged to monoclinic crystal system characteristic of CaHP042H20 crystals.

키워드

Sythesis of Calcium hydrogen phosphate Box-Wilson experimental design.