사염화탄소 및 담도폐쇄 유발 간장장애 가토에서 싸이크로스포린의 약물동태

• 영문명: Pharmacokinetics of Cyclosporine in Rabbits with Carbon Tetrachloride and Bile Duct Ligation-induced Hepatic Disorder
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi) 최병철(Byong Chul Choi) 범진필(Jin Pil Burm)
• 간행물 정보: 『약학회지』제42권 제2호 (1998년), 181~186쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.04.30

영문 초록

This study was attempted to investigate the pharmacokinetics of cyclosporine (10mg/kg, oral) in rabbits with CC14 and bile duct ligation-induced hepatic disorder. The area under the curve (AUC) of blood cyclosporine concentration versus time was significantly increased (p4-induced hepatic disorder. Elimination rate constant (Kel) was significantly decreased (p<0.05, p<0.01) in rabbits with CC14 and bile duct ligation-induced hepatic disorder. Volume of distribution (Vdss) and total body clearance (CLtot) were significantly decreased (p<0.01) in rabbits with CC14-induced hepatic disorder. But Vdss was significantly increased (p4-induced hepatic disorder were 874ng/ml and 2.71 hr, respectively. Cmax and Tmax values in rabbits with bile duct ligation were 105ng/ml and 2.834 hr, respectively. From results of this experiment. It is desirable to do therapeutic drug monitoring of cyclosporine for effective treatment when the cyclosporine is administered to patients with liver disorder m clinical practice.

키워드

Pharmacokinetics cyclosporine CCI4 and bile duct ligation-induced hepatic disorder therapeutic drug monitoring.