국소치료용 구강점막패취의 제제설계 및 약제학적 특성

• 영문명: Formulation and Pharmaceutical Properties of Local Mucoadhesive-Patch Preparation
• 발행기관: 대한약학회
• 저자명: 이계주(Gye Ju Rhee) 서현주(Hyun Joo Suh) 이덕금(Duck Geun Lee) 박종범(Jong Bum Park) 신광현(Kwang Hyun Shin) 황성주(Sung Joo Hwang)
• 간행물 정보: 『약학회지』제42권 제2호 (1998년), 187~195쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.04.30

영문 초록

In order to ameliorate disadvantages of buccal ointments and mucoadhesive tablets used for the treatment of aphthosis, a thin mucoadhesive patch containing triamcinolone acetonide was designed and evaluated for the pharmaceutical properties. The adhesive gel layer consisting of Noveon AA-1, hydroxypropylcellulose-M and ethylcellulose N 100, and the protective gel layer of ethylcellulose N 100, Eudragit RSPO and castor oil have been formulated and various properties such as viscosity of drug gel layer, thickness, in vitro adhesion time, adhesive strength, surface pH, content uniformity and drug release are tested. The mean viscosity of drug-containing gel layer was found to increase with increasing amount of Noveon OAA-1 or hydroxypropylcellulose-M. The optimum formulation showed the thickness of 171 mcm, surface pH of 4.6, in vitro adhesion time of 8 hours and adhesive strength of 272.7g/sheet. The drug content of each patch was relatively homogeneous with the value of 273+/-6.77g. Drug release study showed that compared to mucoadhesive tablet, the patch showed a faster drug release. Drug release was delayed by hydroxypropylcellulose-M, but not by ethylcellulose N 100. The patches prepared were nonirritant and the muco adhesion was better than the commercial product (AftachR) on the market. Based on these results, this mucoadhesive patch is expected to be an effective dosage form for the treatment of aphthosis.

키워드

Triamcinolone acetonide Mucoadhesive patch Bioadhesive polymers Aphthosis.