강활에서 종양괴사인자 생성을 억제하는 활성성분의 분리

• 영문명: Isolation of Inhibitory Components on Tumor Necrosis Factor-alpha Production from Angelica Koreana)
• 발행기관: 대한약학회
• 저자명: 조재열(Jae Youl Cho) 이종수(Jong Soo Lee) 박지수(Ji Soo Park) 박명환(Myung Hwan Park)
• 간행물 정보: 『약학회지』제42권 제2호 (1998년), 125~131쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.04.30

영문 초록

The total ethanol extract of Angelica koreana radix (UmbeUiferae) showed potent inhibitory effect on tumor necrosis factors (TNF-alpha) production from LPS-stimulated RAW264.7 cells in screening studies on 118 Korean medicinal plants. The activity-guided fractionation of the total ethanol extract resulted in the isolation of 4 compounds, including active substances. The chemical structures of the compounds isolated were established by chemical and spectrometric analyses as imperatorin, isoimperatorin, osthol and oxypeucedanin. Among them, osthol, oxypeucedariin and isoimperatorin showed significant inhibitory activities on TNF-alpha production as 54.3+/-2.1%, 33.6+/-1.0% and 17.7+/-3.0%, respectively, at 12.5mcg/ml.

키워드

Angelica koreana radix (Umbelliferae) TNF-α RAW264.7 lipopolysaccharide EUSA imperatorin isoimperatorin osthol oxypeucedanin.