느릅나무 수피 엑스가 흰쥐의 위염, 위궤양 및 발부종에 미치는 영향

• 영문명: The Influence of Methanol Extract of Ulmus davidiana var. japonica Cortex on Gastric Erosion and Ulcer and Paw Edema in Rats
• 발행기관: 대한약학회
• 저자명: 이은방(Eun Bang Lee) 김옥경(Ok Kyung Kim) 정춘식(Chun Sik Jung) 정기화(Ki Wha Jung)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 671~675쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

The bark of Ulmus davidiana var. japonica(Ulmaceae) has been described in traditional books to have diuretic and laxative actions, to ameliorate edematous disease, and to be used in insomnia and gastrointestinal disorders. Thus this study was carried out to elucidate some of the pharmacological activities of the plant extracts. The results obtained in this experiment indicated that its methanol extract elicited remarkable inhibition of HCl-ethanol induced gastric lesion, Shay ulceration and gastric secretion. However, it showed no anti-inflammatory action. The acute toxicity of the extract was low, that is, the minimum lethal dose was more than 2000mg/kg by oral administration in mice. The systematic fractionation of the methanol extract by hexane, ether, ethylacetate and butanol resulted in potent prevention of gastric erosion in butanol and water fractions.