구인(Lumbricus rubellus) 추출물의 혈전 분해 및 항혈전 효과

• 영문명: Fibrinolytic and Anticoagulant Effects of Earthworm, Lumbricus rubellus, Extracts
• 발행기관: 대한약학회
• 저자명: 장정순(Chung Soon Chang) 이철규(Chul Kyu Lee) 신장식(Jang Sik Shin) 조일환(Il Hwan Cho) 서정진(Jung Jin Suh)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 666~670쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

The plasmin activity of euglobulin fraction treated with earthworm extract(EWE) increased concentration dependently when EWE(O.5, 1.0 and 2.0mg each) were added to normal plasma. It was shown that lumbrokinase in EWE may be moved to euglobulin fraction and activated plasminogen. Also anticoagulation and fibrinolysis were studied when EWE(7.5, 30 and 120mg/kg) were added to rat model. Prothrombin time (PT) were 19.7 +/- 3.8, 22.5 +/- 2.5 and 24.5 +/- 5.0 sec, activated partial thromboplastin time (APTT) were 25.7 +/- 5.9, 28.7 +/- 5.2 and 36.5 +/- 19.1 sec. After 15 days, the production of D-dimer were 242.3 +/- 47.4, 250.0 +/- 11.9 and 205.8 +/- 12.2mg/ml plasma, respectively. These data showed that EWE acted on the coagulation factor of intrinsic and extrinsic system.