Friend Anemia Virus에 감염된 BALB/c 생쥐를 이용한 항AIDS약물의 생체내 약효검색

• 영문명: In Vivo Screening Method for the Anti-AIDS Drugs in the BALB/c Mice Inoculated by Anemia Strain of Friend Virus
• 발행기관: 대한약학회
• 저자명: 안형수(Hyung Soo Ann) 염윤기(Yoon Ki Yom) 장영수(Young Soo Chang)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 622~630쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

Inoculation of Friend anemia virus, which was a kind of retro virus such as HIV, results splenomegaly, anemia, the increase of WBC counts and reverse transcriptase activity in serum. These results were due to the inhibition of the differentiation of erythroid progenitor cell by the FVA at the spleen. Using these as index of antiviral effects, we pursued the establishment of in vivo screening method for the new anti-AIDS drugs. Among zidovudine, didanosine and zalcitabine, which were already approved as anti-AIDS drugs, treatment of zidovudine for 18 days in BALB/c mice inoculated with Friend anemia virus resulted the most potent inhibitory effects on the splenomegaly, the increase of WBC counts and reverse transcriptase activity, but did not recover the anemia due to the toxicity of zidovudine itself on the bone marrow. The antiviral effects of zidovudine was reduced in case of zidovudine treatment 7 days after Friend anemia virus inoculation. These results suggested that the sooner treatment of zidovudine would be better improved when the virus was inoculated. Human recombinant interferon alpha itself did not show the antiviral activity against Friend anemia virus and also did not affect the antiviral activity of zidovudine. These results suggested that Friend anemia virus would be used as a tool in vivo screening method for the inhibitor of reverse transcriptase.