WK101에 의한 아나필락시의 억제효과와 작용기전

• 영문명: Inhibitory Effect of Anaphylaxis by WK101 and Mechanism of Action
• 발행기관: 대한약학회
• 저자명: 이영미(Young Mi Lee) 김형룡(Hyung Ryong Kim)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 616~621쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

The effect of WK101 on compound 48/80-induced anaphylaxis was studied in rat. WK101 was found to exhibit a inhibitory activity on the compound 48/80-induced anaphylaxis. WK101 also inhibited the serum histamine release induced in anaphylaxis by compound 48/80. The effect of WK101 on the histamine release from rat peritoneal mast cells was studied. WK101 (10-3~1mg/ml) inhibited the histamine release induced by compound 48/80 (5mcg/ml) in rat peritoneal mast cells. To clarify the mechanism of these inhibitions, we investigated the effects of WK101 on cAMP and intracellular calcium content of rat peritoneal mast cell. The content of cAMP in mast cells, when WK101 was added, was increased transiently, and was significantly increased more 53 fold at 10sec than that of basal cells. Moreover, WK101 inhibited intracellular calcium release induced by compound 48/80. These results suggest that WK101 may be useful for the prevention and treatment of allergy-related disease.