흰쥐에서 제산제와 병용투여된 아세글루타미드 알루미늄의 약물동태 및 위장관 부착

• 영문명: Pharmacokinetics and Gastric Adhesion of Aceglutamide Aluminium on The Combination of Antacid in Rats
• 발행기관: 대한약학회
• 저자명: 조재열(Jae Youl Cho) 남권호(Kweon Ho Nam) 유은숙(Eun Sook Yoo) 유영효(Young Hyo Yu) 박명환(Myung Hwan Park) 박정일(Jeong Hill Park)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 577~584쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

On the combination of antacid, the pharmacokinetics and gastric adhesion of [14C]aceglutamide aluminium complex([14C]AGA) were examined in rats. Specially, this study was focused on the drug interaction that the co-administration of anatacid may affect the oral co-administration of [14C] AGA and antacid(aluminium hydroxide and magnesium hydroxide(AM)), the radioactivity of plasma and urinary recovery was lower than that of [14C]AGA alone administered group. However, the cumulative recovery of radioactivity in feces was increased significantly. The comparative bioavailability of [14C]AGA from the plasma concentration-time curve and urinary recovery was about 60%. In vitro, the effect of antacid on the gastric adhesion of AGA was not significantly different between AGA and AGA/antacid treatment. And it accorded well with the result of in vivo experiment. In conclusion, on the combination of antacid , the oral absorption of AGA was decreased but the gastric adhesion was not affected in respect of drug interaction.