알록산 유도 당뇨흰쥐의 페에서 황산화계의 변화

• 영문명: The Changes of Antioxidant Enzymes in the Lung of Alloxan-induced Diabetic Rats
• 발행기관: 대한약학회
• 저자명: 최형호(Hyung Ho Choi) 고광삼(Kwang Sam Koh) 임동윤(Dong Yoon Lim)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 654~660쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

The present study was attempted to investigate the mechanism of oxidative cellular injuries which occur in diabetic rats by determining changes of antioxidant enzymes activity in the lung of alloxan-induced diabetic rats, the contents of glutathione in the lung, liver, blood samples, and gamma-glutamylcysteine synthetase activities in the liver. Superoxide dismutase activities (SOD), including Cu, Zn-SOD and Mn-SOD, decreased in the lung of diabetic rats compared with those of normal control rats. However, activities of catalase and glutathione peroxidase (GPX) activities were not affected in the lung of diabetic rats. In diabetic rats, glutathione contents in the lung, liver, and blood samples, as well as the activities of gamma-glutamylcysteine synthetase in the livers which is known to be the key enzyme of glutathione biosynthesis, decreased significantly. From these experimental results, it is thought that the decrease in SOD activities in the lung, glutathione contents and gamma-glutamylcysteine synthetase activities in some tissues in alloxan-induced diabetic rats may be the crucial cause of vulnerability to oxidative cellular injuries.