사염화탄소에 의하여 유발된 흰쥐의 간 독성에 미치는 비테인의 효과

• 영문명: The Effect of Betaine on the CCl4-Induced Hepatotoxicity in Rats
• 발행기관: 대한약학회
• 저자명: 김선여(Sun Yeou Kim) 김홍표(Hong Pyo Kim) 이미경(Mi Kyeong Lee) 변순정(Soon Jeong Byun) 김승희(Seung Hee Kim) 문애리(A Ree Moon) 한형미(Hyung Mi Han) 허훈(Hoon Huh) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 538~543쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

Effects of betaine, a major component of Lycii Fructus, on carbon tetrachloride intoxicated rats were evaluated. Histological studies showed that betaine had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication. Betaine, whether it was administrated simultaneously or prior to carbon tetrachloride, prevented or retarded the elevation of liver-weight/body-weight ratio due to the carbon tetrachloride intoxication. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride intoxication. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride in rat.

키워드

Liver-weight/body-weight ratio carbon tetrachloride cytochrome P-450 7-ethoxycoumarin-O-deethylase fatty liver glutathione-S-transferase glutamic pyruvic transaminase.