칼륨채널 활성물질 Lemakalim의 고칼륨혈증 및 저칼륨혈증에서의 심기능에 대한 영향 및 항 고혈압작용

• 영문명: Pharmacodynamics of Potassium Channel Opener Lemakalim in the Isolated Rat Hearts and Conscious SHRs under Hyperkalemic and Hypokalemic Condition
• 발행기관: 대한약학회
• 저자명: 신홍섭(Hong Sub Shin) 신화섭(Hwa Sup Shin) 권광일(Kwang Il Kwon)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 463~475쪽, 전체 13쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

Pharmacological effects of lemakalim on cardiovascular system were investigated using isolated rat hearts and conscious SHRs subjected to hyperkalemic and hypokalemic condition. In the isolated hearts perfused with normal physiological salt solution(4.7mM KCl), lemakalim increased cardiac function and coronary flow, and these effects were significantly potentiated under hypokalemic(l.2, 2.5mM KCl), but attenuated under hyperkalemic(10mM KCl) condition. In conscious SHRS, lemakalim(O.1, 0.2, 0.3mg/kg, p.o.) produced a dose-related decrease in systolic blood pressure, the maximal hypotensive effect being reached around 0.5 hr after dosing. The intensity and the duration of hypotensive effect of lemakalim were significantly increased when administered in combination with dihydrochlorothiazide (2mg/kg, p.o.), but decreased with triamterene(32mg/kg, p.o.). It appears that the differential effects of two types of diuretics on the hypotensive action of lemakalim are due to their hypokalemic and hyperkalemic action, respectively. It is conclued that the concomitant use of K+ channel openers and hypokalemic diuretics may be an appropriate model of combination therapy in the treatment of hypertension.

키워드

Lemakalim hyperkalemia hypokalemia dihydrochlorothiazide triamterene.