한국산 고등균류 만가닥버섯의 항암성분

• 영문명: Studies on Constitutents of the Higher fungi of Korea. Antitumor Components of the Basidiocarps of Hypsizigus mamoreus
• 발행기관: 대한약학회
• 저자명: 박성미(Sung Mee Park) 진미림(Mi Rim Jin) 김진숙(Jin Sook Kim) 최응칠(Eung Chil Choi) 김병각(Byong Kak Kim)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 490~498쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

To find antitumor components in the hot water extract from the basidiocarps of Hypsizigus mamoreus. protein-bound polysaccharides were purified and fractionated by DEAE-cellulose ion exchange column chromatography and Sepharose CL-4B gel filtration chromatography. When a dose of 20mg/kg/day was injected intraperitoneally into ICR mice. fraction IV of the component showed the highest inhibition ratio of 73.8% against the count of hemolytic plaque forming cells in mice to 3.2 times. when IV was about 30 KD and the fraction was composed of 76.1% polysaccharide and 4.9% protein. The hexosamine was detected in all the fractions, showing that the polysaccharide and protein moieties were bound each other.

키워드

Hypsizigus mamoreus basidiocarps protein-bound polysaccharides tumor inhibition ratio hemolytic plaque forming cells.