Protocatechuic acid 및 Gallic acid 유도체들의 항 혈전작용

• 영문명: Anti-thrombotic Effects of Analogs of Protocatechuic Acid and Gallic Acid
• 발행기관: 대한약학회
• 저자명: 윤혜숙(Hye Sook Yun-Choi) 강삼식(Sam Sik Kang) 김문희(Moon Hee Kim) 정기화(Ki Hwa Jung)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 453~457쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

Platelet anti-aggregating activities were tested with analogs of protocatechuic acid and garlic acid. Six of them which showed comparable inhibitory effects with aspirin against collagen induced platelet aggregation were selected and their anti-thrombotic effects were evaluated in the mouse thrombosis model and compared with those of aspirin and paeonol. At the dose of 50mg/kg, p.o., ethyl gallate(13) treated group showed higher % of recovery within 6 min of thrombotic challenge and lower mortality within 5 min than aspirin treated group.

키워드

anti-platelet anti-thrombotic ethyl gailate aspirin paeonol.