오메프라졸 함유 직장좌제의 약물속도론적 연구

• 영문명: Pharmacokinetics of Omeprazole from Rectal Suppositories
• 발행기관: 대한약학회
• 저자명: 이창현(Chang Hyun Lee) 황성주(Sung Joo Hwang) 권광일(Kwang Il Kwon) 이계주(Gye Ju Rhee)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 427~436쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

The pharmacokinetics and relationship between in vitro dissolution and in vivo fraction absorbed were investigated after intravenous(iv) injection of omeprazole(OMZ), oral administration of OMZ capsules and rectal administration of 8 types of suppositories. The plasma concentration of OMZ (Cp)-time (t) curve after iv. administration fitted a two-compartment open model and the equation which best fitted the p kinetics of OMZ was Cp = 13.936 e-8.78t + 2.973 e-0.716t. The bioavailabilities of OMZ in Witepsol H15 base (Supp-2) and PEG 4000 base (Supp-6) suppositories were 40.7% and 33.4%, respectively, which are higher(p<0.001) than 13% of oral administration of capsule. The avoidance fractions of the first-pass metabolism for Supp-2 and Supp-6 suppositiories were 31.8% and 23.4%, respectively, suggesting that the rectal application of OMZ may be a more adequate route of administration than oral one.

키워드

Omeprazole Witepsol H15 PEG 4000 Pharmacokinetics Bioavailability Avoidance fraction of first-pass metabolism.