리팜피신에 내성인 Bifidobacterium bifidum 균주개발

• 영문명: Development of Bifidobacterium bifidum Strains Resistant to Rifampicin
• 발행기관: 대한약학회
• 저자명: 최응칠(Eung Chil Choi) 고성열(Sung Youl Ko) 김희선(Hee Sun Kim) 최성숙(Sung Sook Choi) 김숙경(Sook Kyung Kim) 김병각(Byoung Kak Kim)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 483~489쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

Bifidobacterium bifidum, one strain of medical preparations being on the market for human intestinal disorder, is very sensitive to rifampicin. If this preparation is taken with rifampicin, its therapeutic effect can't be expected. To develope rifampicin resistant mutants, B. bifidum was treated with N-methyl-N''-nitro-N-nitrosoguanidine(MNNG). All of thirty strains grown on the plates containing 10 mcg/ml rifampicin were over 1,000 times more resistant to rifampicin than parental strain and they were identified as B. bifidum by fructose-6-phosphoate phosphoketolase test. Three strains out of thirty, which produced almost same amount of organic acid as parental strain, were selected for further studies. They showed identical growth inhibition activity aganist E. coli compared with that of parental strain. And rifampicin was not inactivated.