페나진 유도체의 합성과 항균성 - 7-치환-2,3-디히드록시페나진-5,10-디옥시드류의 합성 및 항균성 -

• 영문명: Synthesis and Antimicrobial Activity of Phenazine Derivatives - Synthesis and Antimicrobial Activity of 7-Substituted -2,3-dihydroxyphenazine-5,10-dioxides -
• 발행기관: 대한약학회
• 저자명: 이만길(Mak Kil Lee) 김호식(Ho Sik Kim) 한성욱(Sung Wook Han)
• 간행물 정보: 『약학회지』제36권 제5호 (1992년), 440~448쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.10.29

영문 초록

7-Substituted 2, 3-dihydroxyphenazine 5, 10-dioxides were synthesized by the reaction of 1,2,4-trihydroxybenzene with 6-substituted benzofuroxan derivatives which had been obtained from aniline derivativies bearing methoxy, methyl, acetyl and nitro group at the para position. 2,3-Dihydroxyphenazine 5,10-dioxide was also prepared by the reaction of 1,2,4-trihydroxybenzene with benzofuroxan. The antimicrobial activities of these phenazine dioxide were investigated in terms of minimum inhibitory concentration by the common twofold dilution technique. It was observed that the antimicrobial activity of the phenazine dioxides bearing electron releasing substituents was stronger than that of those bearing electron withdrawing substitutents. From this result, it was concluded that the antimicrobial activity of phenazine dioxide derivatives has a direct relationship with the electronic effect of the substituents.