나린게닌의 항균력에 미치는 관련 후라보노이드의 병용효과

• 영문명: Antimicrobial Effects of Naringenin alone and in Combination with Related Flavonoids
• 발행기관: 대한약학회
• 저자명: 한성순(Seong Sun Han) 이종길(Chong Kil Lee) 김영소(Young Soe Kim)
• 간행물 정보: 『약학회지』제36권 제5호 (1992년), 407~411쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.10.29

영문 초록

As part of our search for less toxic antimicrobial substances from natural resources, naringin was isolated from feels of Citri fructus and then hydrolyzed to naringenin. The antimicrobial activity of naringenin was examined by measuring the minimal inhibitory concentration(MIC) against fourteen species of bacteria. The antimicrobial activity of naringenin in combination with rutin or hesperetin was evaluated by checkerboard method. Among fourteen species tested, the antimicrobial activity of naringenin was the most prominant against Staphylococcus aureus and Shigella boydii showing MIC of 100mcg/ml for both species. Combinations of naringenin with rutin or hesperetin showed synergism against several species of bacteria, but no antagonism was observed.