흰쥐에서 할로페리돌에 의해서 유발된 강경증에 미치는 후구 적출의 영향

• 영문명: Effects of Olfactory Bulbectomy on Catalepsy Induced by Haloperidol in Rats
• 발행기관: 대한약학회
• 저자명: 전승호(Seoung Ho Chun) 김선장(Seon Jang Kim) 배기환(Ki Hwan Bae) 이순철(Soon Chul Lee)
• 간행물 정보: 『약학회지』제36권 제5호 (1992년), 427~432쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.10.29

영문 초록

We attempted to clarify the effect of bilateral olfactory bulbectomy on catalepsy induced by haloperidol in rats. The incidence of catalepsy induced by haloperidol remarkably increased after lesion of olfactory bulb, which was significantly inhibited by L-5-hydroxytryptophan, L-DOPA, and ginseng''s total saponin but reserpine and alpha-methyl-p-tyrosine were ineffective. The dopamine content of brain was significantly decreased by olfactory bulbectomy, but this result was reversed by ginseng''s total saponin.