Clobazam이 가토 혈중 주정 농도에 미치는 영향에 관한 실험적 연구

• 영문명: Effects of Clobazam on Blood Alcohol Level in Rabbits
• 발행기관: 대한신경정신의학회
• 저자명: 윤중석 박정수
• 간행물 정보: 『신경정신의학』제20권 제4호, 417~422쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1981.11.30

영문 초록

Clobazam is the first anxiolytic . drug which belongs to the class of the 1,5-rather than the 1 ,4-benzooiazepines. The structural difference beween clobazam and other benzodiazepines is that the Nin the heterocyclic ring is in positions 1 and 5 rather than in position 1 and 4. This drug possesses all the pharm acological properties of an anti-anxiety agent with out appreciable sedative and depressive side-effects. Investigators suggested that any new psychotropic drug should be tested for its . interaction with alcohol, because it might precipitate the risk situation in case of consuming alcohol concurrently. Recently it has been reported that various psychotropic agents tended to elevate the blood alcohol level. In view of these reports, the author conducted an animal experiment to investigate the effect of clobazam on the blood alcohol level in rabbits. Material and method 1. The experimental work was done on mature rabbits of both sexes, weighing about 2kg. 2. The experimental animals were divide into two groups； the control and the experimental group. 3. The control group was given alcohol alone. 4. The experim ental group was divided into 4 subgroups； a) alcohol plus clobazam, lO mg /kg of body weight daily for 5 days, h ) alcohol plus clobazam, lO mg /kg of body weight daily for 10 days. c) alcohol plus clobazam, 40mg/kg of body weight daily for 5 days. d) alcohol plu s clobazam, 40mg/kg of body weight daily for lOdays. 5. Clobazam was given orally in a single daily dose at a fixed time. The last dose was given one hour and a half before alcohol admin istration . 6. In all groups 20% ethanol solution was slowly given in a dose of 5. Omg/kg of body weight for 5 minutes by intravenous routes. 7. All of the blood specimens were obtained by cardiac puncture at 15 and 45 minutes respectively, after alcohol administration. 8. The blood alcohol level was determined by Cavett’ s method. Results 1. Alcohol plus clobazam , 10mg/kg of body 、 weight daily for 5 days. C lobazam did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration , (respectively, p > 0 . 05) 2. Alcohol plus clobazam, 10mg/kg of body weight daily for 10 days. In this group, there was no significant change in the blood level at both 15 and 45 minutes after alcohol administratio n ,respectively,p > 0 . 05) 3. Alcohol plus clobazam, 40mg/kg of body weight daily for 5 clays. . In th is group, there was no sig nicant change in the blood level at both 15 and 45 minutes after alcohol administration (respectively,p > 0 .0 5 ). 4. Alcohol plus clobazam, 40mg/kg of body weight daily for 10 days. In th is group, there was no significant change in the blood level at both 15 and 45 minutes after alcohol administration (respectively,p〉0 .05). Conclusion 1. Clobazam, when administered orally in a dose of lO mg /kg of body weight daily for 5 and 10 days, did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol admin istration . 2. Clobazam, when administered orally in a dose of 40mg/kg of body weight daily for 5 or 10 days, did not change the blood a lcohol level significantly a t both 15 and 45- minutes after alcohol administration.

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