자동합성장치에 따른 ¹⁸F-FDG의 방사선분해 평가

• 영문명: Radiolysis Assessment of ¹⁸F-FDG According to Automatic Synthesis Module
• 발행기관: 대한핵의학기술학회
• 저자명: 김시활(Si Hwal Kim) 김동일(Dong Il Kim) 지용기(Yong Gi Chi) 최성욱(Sung Wook Choi) 최춘기(Choon Ki Choi) 석재동(Jae Dong Seok)
• 간행물 정보: 『핵의학기술』Vol.16 No.1, 8~11쪽, 전체 4쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2012.04.30

영문 초록

Purpose : Among quality control items, the radiochemical impurity must be below 10% of total radioactivity. In this regard, as the recently commercialized automatic synthesis module produces a large amount of ¹⁸F-FDG, radiolysis of radiopharmaceuticals is very likely to occur. Thus, this study compared the changes in radiochemical purity regarding radiolysis of ¹⁸F-FDG according to automatic synthesis module. Materials and methods : Cyclotron (PETtrace, GE Healthcare) was used to produce ¹⁸F and automatic synthesis module (FASTlab, Tracerlab MX, GE Healthcare) was used to achieve synthesis into FDG. For radiochemical purity, Radio-TLC Scanner (AR 2000, Bioscan), GC (Gas Chromatograph, Agilent 7890A) was used to measure the content of ethanol included in ¹⁸F-FDG. Glass board applied with silica gel (1 × 10 cm) was used for stationary phase while a mixed liquid formed of acetonitrile and water (ratio 19:1) was used for mobile phase. High-concentration and low-concentration ¹⁸F-FDG were produced in each synthesis module and the radiochemical purity was measured every 2 hours. Results : The purity in low-concentration (below 2.59 GBq/mL) was measured as 99.26%, 98.69%, 98.25%, 98.09% in Tracerlab MX and as 99.09%, 97.83%, 96.89%, 96.62% in FASTlab according to 0, 2, 4, 6 hours changes, respectively. The purity in high-concentration (above 3.7 GBq/mL) was measured as 99.54%, 96.08%, 93.77%, 92.54% in Tracerlab MX and as 99.53%, 95.65%, 92.39%, 89.82% in FASTlab according to 0, 2, 4, 6 hours changes, respectively. Also, ethanol was not detected in GC of ¹⁸F-FDG produced in FASTlab, while 100~300 ppm ethanol was detected in Tracerlab MX. Conclusion : Whereas the change of radiochemical purity was only 3% in low-concentration ¹⁸F-FDG, the change was rapidly increased to 10% in high-concentration. Also, higher radiolysis were observed in ¹⁸F-FDG produced in FASTlab than Tracerlab MX. This is because ethanol is included in the synthesis stage of Tracerlab MX but not in the synthesis stage of FASTlab. Thus, radiolysis is influenced by radioactivity concentration than the inclusion of ethanol, which is the radioprotector. Therefore, after producing high-concentration ¹⁸F-FDG, the content must be diluted through saline to lower concentration.

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키워드

¹⁸F-FDG Radiochemical purity TLC Radiolysis