Random Energy Model for the B Cell Immune Response and the Original Antigenic Sin

• 발행기관: 한국자료분석학회
• 저자명: 강영경(Yung-Gyung Kang)
• 간행물 정보: 『Journal of The Korean Data Analysis Society (JKDAS)』Vol.7 No.3, 711~720쪽, 전체 10쪽
• 주제분류: 자연과학 > 통계학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

The adaptive immune system defends our body against infection and provides the specific protective immunity that prevents reinfection. Antigen-specific lymphocytes, B cells and T cells, recognize and eliminate any foreign antigens and then generate a great number of memory lymphocytes which allow a more rapid and effective response upon reinfection. We propose a random energy model for the B cell immune response and expound the original antigenic sin of B cells, which is a term describing immune interference due to antigenic change. We present the simulation results of the random energy model under various parameters. This work has applications to understanding vaccination against continually mutating viruses.

목차

1. Introduction

2. B Cell Immune Response

3. Random Energy Model and the Simulation Scheme

4. Simulation Results

5. Concluding Remarks

References

키워드

B cell immune response original antigenic sin random energy model