신우황청심원의 심혈관계에 대한 약효

• 영문명: Pharmacological Actions of New Woohwangchungsimwon Pill on Cardiovascular System
• 발행기관: 대한약학회
• 저자명: 조태순(Tai Soon Cho) 이선미(Sun Mee Lee) 허인회(In Hoi Huh) 안형수(Hyung Soo Ann) 권광일(Kwang Il Kwon) 박석기(Seok Ki Park) 심상호(Sang Ho Shim) 신대희(Dae Hee Shin) 박대규(Dai Kyu Park) 김낙두(Nak Doo Kim)
• 간행물 정보: 『약학회지』제41권 제6호 (1997년), 802~816쪽, 전체 15쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.31

영문 초록

In order to investigate the pharmacological properties of New Woohwangehungsimwon Pill (NWCH). Effects of Woohwangehungsimwon Pill (WCH) and NWCH were compared using various experimental models. In isolated rat aorta, NWCH and WCH showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10-6M) without regard to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not affect significantly the relaxative effects of NWCH and WCH. NWCH and WCH inhibited the vascular contractions induced by acethylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats(SHRs), NWCH and WCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, these had no effects on parameters of action potential at low doses, whereas inhibited the cardiac, contractility at high doses. Furthermore, these had a significant inhibitory effects on heart acceleration in normotensive rats and SHRs. These results suggested that NWCH and WCH have weak cardiovascular effects, and that there is no significant differences between two preparations.

키워드

New Woohw angchungsimwon Pill Woohw angchungsim won Pill cardiovascular system SHR negative inotropic effect action potential.