정상 및 손상된 흰쥐 피부에 국소 적용된 125I-rhEGF의 체내 이행

• 영문명: Body Distribution of 125I-rhEGF Across Normal and Damaged Rat Skins
• 발행기관: 대한약학회
• 저자명: 이정욱(Jeong Uk Lee) 정석재(Suk Jae Chung) 이민화(Min Hwa Lee) 심창구(Chang Koo Shim)
• 간행물 정보: 『약학회지』제41권 제6호 (1997년), 730~736쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.31

영문 초록

Distribution of radioactivity in the skin tissues, subcutaneous tissues, blood and body organs was examined following topical application of 125I-rhEGF (0.4 mcCi), in the form of a Pluronic F-127 gel, on the normal and damaged (burned and stripped) skins of SD male rats. The radioactivity in the skin tissues and subcutaneous tissues was 3-5 times higher for the damaged skins than for the normal skin. But pretreatment of the skin with rhEGF (1mcg) twice at 24 hr dose intervals affected the distribution of the radioactivity yielding the order of burned skin> stripped skin=normal skin. The decrease for the stripped skin by the pretreatment might be related either to the pathophysiological change of the skin or to the down regulation of the EGF receptor. Liver showed the highest radioactivity in amount following single and multiple administration of the drug to the normal and damaged skins. But,in concentration, the kidney and stomach showed higher value than the liver which is consistent with that kidney is a major eliminating organ of EGF and that EGF exerts its pharmacological effect specifically for the stomach.

키워드

Epidermal growth factor(EGF) single dose multiple dose burned skin stripped skin radioactivity organ distribution.