트롬복산 A2와 트롬복산 A2 수용체 길항제의 활성형태

• 영문명: Active Conformation of Thromboxane A2 and Thromboxane A2 Receptor Antagonists
• 발행기관: 대한약학회
• 저자명: 이종달(Jong Dal Rhee) 도성탁(Seong Tak Doh)
• 간행물 정보: 『약학회지』제41권 제6호 (1997년), 765~772쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.31

영문 초록

Conformational analyses on thromboxane A2 (TxA2) and thromboxane A2 receptor antagonists (TxRA) were carried out by molecular mechanics method. Based on the assumption that active conformer is the nonintrahydrogen bonding and more stable former of TxA2 and TxRA, the molecular structural requirements for potent TxA2 receptor antagonists are like below: 1) The distance is 5.0-5.6 A.U. between C atom of carboxyl group and S atom of sulfonyl group or C atom which is bonded to hydroxyl group in the active conformers. 2) The putative active conformers of TxA2 and TxRAs are hairpin-like forms.

키워드

Thromboxane A2 Thromboxane A2 receptor antagonists Conformation analysis.