l-디프레닐 투여 후 흰쥐 뇨중 메스암페타민 및 암페타민의 거울상이성질체의 가스크로마토그라피에 의한 분석

• 영문명: Gas Chromatographic Analysis of Optical Isomers of Methamphetamine and Amphetamine After Administration of l-Deprenyl(Selegiline) to Rats
• 발행기관: 대한약학회
• 저자명: 김은미(Eun Mi Kim) 김선춘(Sun Cheun Kim) 정희선(Hee Sun Chung) 유영찬(Young Chan Yoo)
• 간행물 정보: 『약학회지』제41권 제6호 (1997년), 698~703쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.31

영문 초록

Recently, l-deprenyl (selegiline), a relative new antiparkinson`s drug, has been marketed in Korea. As its metabolites, l-methamphetamine and l-amphetamine, are the enantiomers of illicit drugs,d-methamphetamine and d-amphetamine, a method for analysis of enantiomers of methamphetamine and amphetamine in rat urine was investigated. The optical isomers of methamphetamine and amphetamine were analyzed with the chiral derivatizing reagent (S)-(-)-N-(trifluoroacetyl)-prolyl chloride (l-TFP), which was used to form the diastereomers of methamphetamine and amphetamine. And all diastereomers (l-TFP -l-AM, lTFP-d-AM, l-TFP-l-MA & l-TFP-d-MA) were well resolved by capillary gas chromatography. After administration of 10mg/kg l-deprenyl to rat, l-methamphetamine and l-amphetamine were detected without autoracemization to the d form in all urine samples collected during 24hrs, and the ratios of l-amphetamine/l-methamphetamine were 1.1~3.3. l-Amphetamine was detected in only 3 out of 8 urine samples collected during 24~48hrs where as no l-methamphetamine was detected in all cases.

키워드

l-deprenyl optical isomers of methamphetamine and amphetamine (S)-(-)-N-(trifluoroacetyD-prolyl chloride gas chromatography.