삼백초의 세포독성 성분연구

• 영문명: Studies on the Cytotoxic Constituent of Saururus chinensis(LOUR.) BAILL.
• 발행기관: 대한약학회
• 저자명: 박시경(Si Kyung Park) 오갑진(Gab Jin Oh) 배춘일(Choon Il Bae) 김종현(Hyun Jong Kim) 환완식(Wan Sik Han) 정순간(Sun Gan Chung) 조의환(Eui Whan Cho)
• 간행물 정보: 『약학회지』제41권 제6호 (1997년), 704~708쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.31

영문 초록

In our search for bioactive natural products with antitumor activity, we have valuated various extracts of Saururi Herba (Saururaceae), which has been used in traditional medicine for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The hexane extract of the aerial part of this plant was found to show a potent cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A549, HCT15, SKOV3, HEP-3B) in vitro. Using cytotoxicity-guided chromatographic separation of the hexane extract, cytotoxic constituent: 10-aminomethyl-3-hydroxy-4-methoxyphenanthrene-carboxylic acid lactam, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.

키워드

Saururus chinensis Saururaceae cytotoxic effect 10~aminomethyl~3-hydroxy-4-methoxyphenanthrene-carboxylic acid lactam (sauristolactam) phenanthrene alkaloid.