입체선택적인 분자내 [2+2] 환화반응을 이용한 광학활성 Bicyclo[4.2.0]octanone의 합성

• 영문명: Synthesis of The Optically Active Bicyclo[4.2.0]octanone by Stereoselective Intramolecular[2+2]Cycloaddition
• 발행기관: 대한약학회
• 저자명: 심필종(Pil Jong Shim) 김희두(Hee Doo Kim)
• 간행물 정보: 『약학회지』제41권 제6호 (1997년), 714~717쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.31

영문 초록

Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.

키워드

Stereoselective intramolecular[2+2]cycloaddition Olefin-keteniminium salt L-Glutamic acid Optically active bicyclo[4.2.0]octanone.