침향의 항알레르기 효과

• 영문명: Antiallergic Effect of Aquilariae Lignum
• 발행기관: 대한약학회
• 저자명: 김윤철(Youn Chul Kim) 정세준(Sei Joon Jeong) 김형민(Hyung Min Kim)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 255~259쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

Effects of the aqueous extract of Aquilariae Lignum (Thymelaeaceae) on the allergic reactions were investigated. Oral administration of this extract (50, 250, and 500mg/kg) exhibited a dose-dependent inhibition on passive cutaneous anaphylactic reactions in rats. Administrations of this extract (500mg/kg, i.p.) at 60 min before and 5, 10 min after the compound 48/80 treatment (8mg/kg, i.p.) decreased the mortality rates to 0, 0, and 14.2%, respectively. The aqueous extract of Aquilariae Lignum (0.05 ~ 1.6mg/ml) showed a dose-related inhibition on histamine release from rat peritoneal mast cells. The morphological examination also clearly showed that the aqueous extract of Aquilariae Lignum prevented the degranulation of mast cells in rats.

키워드

Aquilariae Lignum Thymelaeaceae Allergic reactions Histamine Mast cells.