지리바꽃 괴경의 알카로이드

• 영문명: Alkaloids from the Tuber of Aconitum chiisanense
• 발행기관: 대한약학회
• 저자명: 이무택(Moo Taek Lee) 성환길(Hwan Kil Sung) 황완균(Wan Kyunn Whang) 김일혁(Il Hyuk Kim)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 161~173쪽, 전체 13쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

Tuber of Aconitum chiisanense(Ranunculaceae) a specific medicinal plant in Korea, which is known to have the activity to recover reduced metabolism of feeble patients and has been used to symptoms such as pain, paralysis, atonia and coldness of extremities, etc. were studied. The powdered tubers of the plant were extracted with 10% EtOH 3 times and the combined extract was dissolved in 1N HCl solution and washed with ethyl acetate. The aqueous layer was basified with solid Na2CO3 and extracted with CHCl3 to obtain an alkaloidal fraction. The alkaloidal fraction was subjected to column chromatography using silica gel, alumina and Sephdex LH 20, etc. From the alkaloidal fraction, five diterpene alkaloids, mesaconitine, aconitine, hypaconitine, 8-O-ethyl 14-benzoylmesaconine and talatizamine, were isolated and identified on the basis of their physico-chemical properties and spectroscopic evidences(1H-, 13C-NMR, EI-MS, IR, 2D-NMR) respectively. Especially the Compound IV, 8-O-ethyl 14-benzoylmesaconine, was assumed to be an artifact resulting from mesaconitine during extraction procedures. The contents of mesaconitine, aconitine and hypaconitine in the mother tuber of this plant were 0.300%, 0.024%, and 0.068%. And that of the attached tuber(new one) of this plant were 0.336%, 0.034% and 0.240% respectively.

키워드

Aconitum chiisanense Ranunculaceae tuber mesaconitine aconitine hypaconitine 8-0-ethyl 14-benzoylmesaconine talatizamine.