항진균제 알릴아민류의 합성과 생물학적 평가

• 영문명: Synthesis and Biological Evaluation of Allylamine Antimycotics
• 발행기관: 대한약학회
• 저자명: 정병호(Byung Ho Chung) 조원제(Won Jea Cho) 천승훈(Seung Hoon Cheon) 박면지(Myun Ji Park) 유진철(Jin Cheol Yoo) 천문우(Moon Woo Chun)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 187~194쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

For the development of antifungal agents, modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole, piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds, (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyridylmethyl)amine(3f) showed relatively noticeable activity(MIC=50mcg/ml). On the other hand, the other compounds had no activity.

키워드

trans-Cinnamaldehyde 2-amino-6-fluoroben2iothiazole 4-(3-axninopropyl) morpholine 4-(2-aminoethy1) morpholine 4-(aminomethyl) piperidine 4-(aminomethyl) pyridine 3-(aminomethyl)py-ridine 2-(aminomethyl)pyridine.