위암 환자에서 반코마이신의 임상약물동태

• 영문명: Clinical Pharmacokinetics of Vancomycin in Gastric Cancer Patients
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi) 장일효(Il Hyo Chang) 범진필(Jin Pil Burm)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 195~202쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

The purpose of this study was to determine pharmacokinetic parameters of vancomycin using two point calculation(TPC) and Bayesian methods in 16 Korean normal volunteers and 15 gastric cancer patients. Nonparametric expected maximum(NPEM) algorithm for calculation of population pharmacokinetic parameter was used, and these parameters were applied for clinical pharmacokinetic parameters by Bayesian analysis. Vancomycin was administered 1.0g every 12 hrs for 3 days by IV infusion over 60 minutes. The volume of distribution(Vd), elimination rate constant(Kel) and total body clearance(CLt) of vancomycin in normal volunteers using TPC method were 0.34 +/- 0.06 L/kg, 0.19 +/- 0.01 hr-1 and 4.08 +/- 0.93 L/hr, respectively, The Vd, Kel and CLt of vancomycin in gastric cancer patients using TPC method were 0.46 +/- 0.06 L/kg, 0.17 +/- 0.02 hr-1 and 4.84 +/- 0.57 L/hr respectively. There were significant differences(p2)-1, 0.631 +/- 0.0036 L/kg in gastric cancer patients using NPEM algorithm respectively. The Vd and Kel were 0.63 +/- 0.005 L/kg, 0.15 +/- 0.027 hr-1 for gastric cancer patients using Bayesian method. There were significant differences(p<0.05) in vancomycin pharmacokinetics between Bayesian and TPC methods. It is considered that the population parameter in the patient population is necessary for effective Bayesian method in clinical pharmacy practise.

키워드

Population pharmacokinetics Vancomycin Gastric cancer Bayesian Nonparametric expected maximum algorithm.